Molecular pathogenesis of ADPKD: The polycystin complex gets complex

Molecular pathogenesis of ADPKD and development of targeted therapeutic options.

Autosomal dominant polycystic kidney disease (ADPKD) is a common genetic disease characterized by formation and progressive enlargement of cysts in kidneys, liver and other organs, leading to end stage renal disease by the fifth decade [1]. Mutations in the PKD1 gene encoding polycystin-1 are responsible for 85% of ADPKD cases, while mutations in the PKD2 gene cause 15% of ADPKD cases with a le...

The tuberous sclerosis complex gets fatter

The molecular pathogenesis of pancreatic cancer: clarifying a complex circuitry.

The preponderance of pancreatic malignancies is constituted by pancreatic ductal adenocarcinomas, abbreviated as either PDA or PDAC in the literature and used interchangeably with the generic term pancreatic cancer. Other types of pancreatic malignancies, albeit uncommon and not meant to be exhaustive, include neuroendocrine tumors, acinar cell carcinomas, lymphomas, sarcomas, serous cystadenoc...

Identification of Mycobacterium Tuberculosis Complex, Using Molecular Methods

Abstract Background and Objective: A high level of homogeneity observed within all bacteria in the Mycobacterium tuberculosis complex makes a property that seriously challenges traditional biochemical-based identification methods of these pathogens in the laboratory. The work presented here was conducted to characterize Mycobacterium tuberculosis complex isolates in Golestan, Northern Iran. ...

PREPARATION AND MOLECULAR STRUCTURE OF 2-BENZYLAMINOPYRIDINE COPPER(1) COMPLEX

2-Benzylaminopyridine (HBAP) reacts with NaH in THF and generates the sodium salt (NaBAP). Further reaction of [Cu(TMEDA) ] [CuCl ] with one equivalent of this ligand in THF leads to the formation of a dimeric Cu(1) complex, [Cu (BAP)] . H 0. The molecular structure has been determined by using a single-crystal X-ray diffraction method. The yellow compound crystallizes in the monoclinic s...